TY - JOUR
T1 - A multi-centre, web-accessible and quality control-checked database of in vivo MR spectra of brain tumour patients
AU - Julià-Sapé, Margarida
AU - Acosta, Dionisio
AU - Mier, Mariola
AU - Arùs, Carles
AU - Watson, Des
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Objective: To describe an Internet-accessible database that contains validated in vivo MR spectra and clinical data of brain tumour patients. Materials and methods: All data from patients entering the INTERPRET project (International Network for Pattern Recognition of Tumours Using Magnetic Resonance, 〈http:// azizu.uab.es/INTERPRET〉) were stored in a web-accessible database (iDB) and selected using its query functionality. Criteria for selection were that the case had a single voxel (SV) short-echo (20-32 ms) 1.5 T spectrum acquired from a nodular region of the tumour, that the voxel had been positioned in the same region as where subsequent biopsy was obtained, that the short-echo spectrum had not been discarded because of acquisition artefacts or other reasons, and that a histopathological diagnosis was agreed among a committee of neuropathologists. When the spectra were obtained from normal volunteers or were of abscesses or clinically proven metastases, biopsy was not required. Results: A subset of 304 cases (22 normal volunteers and 282 tumour patients) was obtained. These cases were migrated to another similar database (validated-DB). Conclusion: The validated-DB complies with ethics regulations and represents the population studied. It is accessible by neuroradiologists willing to use information provided by MRS to help in the non-invasive diagnosis of brain tumours. © ESMRMB 2006.
AB - Objective: To describe an Internet-accessible database that contains validated in vivo MR spectra and clinical data of brain tumour patients. Materials and methods: All data from patients entering the INTERPRET project (International Network for Pattern Recognition of Tumours Using Magnetic Resonance, 〈http:// azizu.uab.es/INTERPRET〉) were stored in a web-accessible database (iDB) and selected using its query functionality. Criteria for selection were that the case had a single voxel (SV) short-echo (20-32 ms) 1.5 T spectrum acquired from a nodular region of the tumour, that the voxel had been positioned in the same region as where subsequent biopsy was obtained, that the short-echo spectrum had not been discarded because of acquisition artefacts or other reasons, and that a histopathological diagnosis was agreed among a committee of neuropathologists. When the spectra were obtained from normal volunteers or were of abscesses or clinically proven metastases, biopsy was not required. Results: A subset of 304 cases (22 normal volunteers and 282 tumour patients) was obtained. These cases were migrated to another similar database (validated-DB). Conclusion: The validated-DB complies with ethics regulations and represents the population studied. It is accessible by neuroradiologists willing to use information provided by MRS to help in the non-invasive diagnosis of brain tumours. © ESMRMB 2006.
KW - Cancer
KW - Confidentiality
KW - Decision-support systems (DSS)
KW - Neurology
U2 - 10.1007/s10334-005-0023-x
DO - 10.1007/s10334-005-0023-x
M3 - Article
VL - 19
SP - 22
EP - 33
JO - Magnetic Resonance Materials in Physics, Biology, and Medicine
JF - Magnetic Resonance Materials in Physics, Biology, and Medicine
SN - 0968-5243
IS - 1
ER -