A metal-free general procedure for oxidation of secondary amines to nitrones

Carolina Gella, Èric Ferrer, Ramon Alibés, Félíx Busqué, Pedro De March, Marta Figueredo, Josep Font

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73 Citations (Scopus)

Abstract

(Chemical Equation Presented) An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functional groups or existing stereogenic centers, providing rapid access to enantiomerically pure compounds in good yields. © 2009 American Chemical Society.
Original languageEnglish
Pages (from-to)6365-6367
JournalJournal of Organic Chemistry
Volume74
Issue number16
DOIs
Publication statusPublished - 1 Jan 2009

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