A metal-free general procedure for oxidation of secondary amines to nitrones

Carolina Gella; Èric Ferrer; Ramon Alibés; Félíx Busqué; Pedro De March; Marta Figueredo; Josep Font

doi:10.1021/jo901108u

A metal-free general procedure for oxidation of secondary amines to nitrones

Carolina Gella, Èric Ferrer, Ramon Alibés, Félíx Busqué, Pedro De March, Marta Figueredo, Josep Font

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

(Chemical Equation Presented) An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functional groups or existing stereogenic centers, providing rapid access to enantiomerically pure compounds in good yields. © 2009 American Chemical Society.

Original language	English
Pages (from-to)	6365-6367
Journal	Journal of Organic Chemistry
Volume	74
Issue number	16
DOIs	https://doi.org/10.1021/jo901108u
Publication status	Published - 1 Jan 2009

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title = "A metal-free general procedure for oxidation of secondary amines to nitrones",

abstract = "(Chemical Equation Presented) An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functional groups or existing stereogenic centers, providing rapid access to enantiomerically pure compounds in good yields. {\textcopyright} 2009 American Chemical Society.",

author = "Carolina Gella and {\`E}ric Ferrer and Ramon Alib{\'e}s and F{\'e}l{\'i}x Busqu{\'e} and {De March}, Pedro and Marta Figueredo and Josep Font",

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T1 - A metal-free general procedure for oxidation of secondary amines to nitrones

AU - Gella, Carolina

AU - Ferrer, Èric

AU - Alibés, Ramon

AU - Busqué, Félíx

AU - De March, Pedro

AU - Figueredo, Marta

AU - Font, Josep

PY - 2009/1/1

Y1 - 2009/1/1

N2 - (Chemical Equation Presented) An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functional groups or existing stereogenic centers, providing rapid access to enantiomerically pure compounds in good yields. © 2009 American Chemical Society.

AB - (Chemical Equation Presented) An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functional groups or existing stereogenic centers, providing rapid access to enantiomerically pure compounds in good yields. © 2009 American Chemical Society.

U2 - 10.1021/jo901108u

DO - 10.1021/jo901108u

M3 - Article

SN - 0022-3263

VL - 74

SP - 6365

EP - 6367

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 16

ER -

A metal-free general procedure for oxidation of secondary amines to nitrones

Abstract

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