(Chemical Equation Presented) An efficient and metal-free protocol for direct oxidation of secondary amines to nitrones has been developed, using Oxone in a biphasic basic medium as the sole oxidant. The method is general and tolerant with other functional groups or existing stereogenic centers, providing rapid access to enantiomerically pure compounds in good yields. © 2009 American Chemical Society.
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 1 Jan 2009|