A meta-analysis on experimental infections with porcine circovirus type 2 (PCV2)

Anna Tomás, Lana T. Fernandes, Oliver Valero, Joaquim Segalés

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Abstract

A meta-analysis was performed with the aim to identify factors with a relevant influence on the expression of clinical postweaning multisystemic wasting syndrome (PMWS) under experimental conditions. Data from 44 studies were included in the analysis. Several variables were studied: number of pigs in the experiment, intake of colostrum, serological status against porcine circovirus type 2 (PCV2), strain of PCV2 used for inoculation, the route and dose of inoculation, and use of potential triggering factors (such as co-infections, vaccinations, or immunomodulator products). Multiple correspondence analysis and log-linear regression methods were used to establish the relationships between the studied variables and the number of PCV2 infected pigs that developed PMWS. Based on the results of the meta-analysis, the most successful animal experiment aimed to develop PMWS should include: (1) colostrum-deprived pigs, (2) age of inoculation below 3 weeks, (3) high doses of PCV2 inoculum, (4) PCV2 strain from genotype 1, and (5) co-infection with another swine pathogen as a triggering factor. © 2008 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)260-273
JournalVeterinary Microbiology
Volume132
DOIs
Publication statusPublished - 10 Dec 2008

Keywords

  • Experimental infections
  • Meta-analysis
  • Porcine circovirus type 2
  • Postweaning multisystemic wasting syndrome

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