A human tetraploid pachytene spermatocyte as the possible origin of diploid sperm: A case report

Monserrar Codina-Pascual, J. Navarro, J. Egozcue, Jordi Benet

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8 Citations (Scopus)

Abstract

Diploid spermatozoa represent 0.2-0.3% of all spermatozoa in the normal population and cause 8.3% of diandric triploids. Errors in meiosis I and II are the most common mechanisms by which diploid spermatozoa are produced. Endoreduplication before meiosis has been suggested as a possible origin for tetraploid meiocytes, which might, in turn, produce diploid sperm. Synaptonemal complex (SC) spreads of a fertile man were immunolabelled (SCP3, MLH1 and CENP) and hybridized with subtelomere-specific multiplex fluorescent in situ hybridization (stM-FISH) assay for SCs identification. The unexpected finding of a tetraploid pachytene cell and the identification of all of its SCs demonstrate that synapsis and crossover events can occur in human tetraploid cells. Moreover, it indicates that diploid sperm may also originate from mitotic errors (endoreduplication) occurring before meiosis. © 2006 Oxford University Press.
Original languageEnglish
Pages (from-to)1795-1797
JournalHuman Reproduction
Volume21
Issue number7
DOIs
Publication statusPublished - 1 Jan 2006

Keywords

  • Crossing over
  • Diploid sperm
  • stM-FISH
  • Synaptonemal complex
  • Tetraploid pachytene

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