A high extra-virgin olive oil diet induces changes in metabolic pathways of experimental mammary tumors.

Maite Garcia-Guasch, Lourdes Navarro, Vanessa Rivero, Irmgard Costa, Eduard Escrich, Raquel Moral

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Breast cancer is the most common malignancy in women worldwide, and environmental factors, especially diet, have a role in the etiology of this disease. This work aimed to investigate the influence of high fat diets (rich in corn oil or extra virgin olive oil -EVOO-) and the timing of dietary intervention (from weaning or after induction) on tumor metabolism in a seven,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer model in rat. The effects of lipids (oils and fatty acids) have also been investigated in MCF-7 cells. The results have confirmed different effects on tumor progression depending on the type of lipid. Molecular analysis at mRNA, protein and activity level of enzymes of the main metabolic pathways have also shown differences among groups. Thus, the animals fed with the EVOO-enriched diet developed tumors with less degree of clinical and morphological malignancy and showed modified glucose and mitochondrial metabolism when compared to the animals fed with the corn oil-enriched diet. Paradoxically, no clear influence on lipid metabolism by the high fat diets was observed. Considering previous studies on proliferation and apoptosis in the same samples, the results suggest that metabolic changes have a role in the molecular context that results in the modulation of different signaling pathways. Moreover, metabolic characteristics, without the context of other pathways, may not reflect tumor malignancy. The time of dietary intervention plays also a role, suggesting the importance of metabolic plasticity and the relation with mammary gland status when the tumor is induced.

Original languageEnglish
Article number108833
Pages (from-to)108833
Number of pages9
JournalThe Journal of Nutritional Biochemistry
Publication statusPublished - 1 Jan 2022


  • Breast cancer
  • Carcinogenesis
  • Dietary lipids
  • Extra virgin olive oil
  • Glucose metabolism
  • Metabolism


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