A genome-wide association analysis for body, udder, and leg conformation traits recorded in Murciano-Granadina goats

Maria Gracia Luigi-Sierra, Vincenzo Landi, Dailu Guan, Juan Vicente Delgado, Anna Castelló, Betlem Cabrera, Emilio Mármol-Sánchez, Javier Fernández Alvarez, Mayra Gómez-Carpio, Amparo Martínez, Xavier Such, Jordi Jordana, Marcel Amills*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Morphological traits are of great importance to dairy goat production given their effect on phenotypes of economic interest. However, their underlying genomic architecture has not yet been extensively characterized. Herein, we aimed to identify genomic regions associated with body, udder, and leg conformation traits recorded in 825 Murciano-Granadina goats. We genotyped this resource population using the GoatSNP50 BeadChip (Illumina Inc., San Diego, CA) and performed genome-wide association analyses using the GEMMA software. We found 2 genome-wide significant associations between markers rs268273468 [Capra hircus (CHI) 16:69617700] and rs268249346 (CHI 28:18321523) and medial suspensory ligament. In contrast, we did not detect any genome-wide significant associations for body and leg traits. Moreover, we found 12, 19, and 7 chromosome-wide significant associations for udder, body, and leg traits, respectively. Comparison of our data with previous studies revealed a low level of positional concordance between regions associated with morphological traits. In addition to technical factors, this lack of concordance could be due to a substantial level of genetic heterogeneity among breeds or to the strong polygenic background of morphological traits, which makes it difficult to detect genetic factors that have small phenotypic effects.

Original languageAmerican English
Pages (from-to)11605-11617
Number of pages13
JournalJournal of Dairy Science
Volume103
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • genome-wide association study (GWAS)
  • goat
  • morphological trait
  • Murciano-Granadina

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