A European multicentre photopatch test study

Alastair C. Kerr; J. Ferguson; S. H. Ibbotson; R. S. Dawe; A. K. Haylett; L. E. Rhodes; H. Adamski; A. Alomar; E. Serra; C. Antoniou; F. Aubin; M. Vigan; T. Biedermann; J. Fischer; J. L. Bourrain; D. Bruynzeel; T. Rustemeyer; J. M. Carrascosa; M. M.U. Chowdhury; J. dela Cuadra; C. Foti; J. Gardeazabal; D. J. Gawkrodger; A. Gimenez-Arnau; M. Goncalo; A. Goossens; M. Lecha; M. C. Marguery; N. J. Neumann; B. Niklasson; J. L. Peyron; P. Pigatto; R. Spiewak; N. Stone; A. Tanew; P. Thomas; A. Bonnevalle; S. M. Wilkinson; P. Wolf; A. Gruber-Wackernagel; H. C. Wulf

doi:10.1111/j.1365-2133.2012.10857.x

A European multicentre photopatch test study

Alastair C. Kerr, J. Ferguson, S. H. Ibbotson, R. S. Dawe, A. K. Haylett, L. E. Rhodes, H. Adamski, A. Alomar, E. Serra, C. Antoniou, F. Aubin, M. Vigan, T. Biedermann, J. Fischer, J. L. Bourrain, D. Bruynzeel, T. Rustemeyer, J. M. Carrascosa, M. M.U. Chowdhury, J. dela CuadraC. Foti, J. Gardeazabal, D. J. Gawkrodger, A. Gimenez-Arnau, M. Goncalo, A. Goossens, M. Lecha, M. C. Marguery, N. J. Neumann, B. Niklasson, J. L. Peyron, P. Pigatto, R. Spiewak, N. Stone, A. Tanew, P. Thomas, A. Bonnevalle, S. M. Wilkinson, P. Wolf, A. Gruber-Wackernagel, H. C. Wulf

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Abstract

Background The two most common agent groups currently responsible for photoallergic contact dermatitis (PACD) are organic ultraviolet (UV) absorbers in sunscreens and topical nonsteroidal anti-inflammatory drugs (NSAIDs). However, availability of information on the photoallergenic potential of these agents is scarce. Objectives To obtain current information on the frequency of PACD to 19 organic UV absorbers and five topical NSAIDs, including newer agents, in common usage in Europe. Methods A prospective, multicentre photopatch test study was conducted with 1031 patients attending for investigation of suspected PACD in 30 centres across 12 European countries. Results A total of 346 PACD reactions in 200 (19·4%) subjects occurred. PACD was most commonly caused by the topical NSAIDs, ketoprofen (128 subjects) and etofenamate (59 subjects). Of the organic UV absorbers, octocrylene, benzophenone-3 and butyl methoxydibenzoylmethane most frequently elicited PACD. The 'newer' organic sunscreen absorbers rarely led to PACD. There appeared to be an association between the agents ketoprofen, octocrylene and benzophenone-3, with several subjects developing PACD to two or all three agents concomitantly. Allergic contact dermatitis (ACD) was less commonly observed than PACD, comprising 55 reactions in 47 (5%) subjects. Irritant reactions and photoaugmentation and photoinhibition of ACD occurred infrequently. Conclusions The European multicentre photopatch test study has provided current information on the relative frequency of PACD to common photoallergens. Such data will be of value when deciding on which agents to include in a future European 'baseline' photopatch test series. © 2012 The Authors. BJD © 2012 British Association of Dermatologists.

Original language	English
Pages (from-to)	1002-1009
Journal	British Journal of Dermatology
Volume	166
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2133.2012.10857.x
Publication status	Published - 1 May 2012

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Kerr, A. C., Ferguson, J., Ibbotson, S. H., Dawe, R. S., Haylett, A. K., Rhodes, L. E., Adamski, H., Alomar, A., Serra, E., Antoniou, C., Aubin, F., Vigan, M., Biedermann, T., Fischer, J., Bourrain, J. L., Bruynzeel, D., Rustemeyer, T., Carrascosa, J. M., Chowdhury, M. M. U., ... Wulf, H. C. (2012). A European multicentre photopatch test study. British Journal of Dermatology, 166(5), 1002-1009. https://doi.org/10.1111/j.1365-2133.2012.10857.x

@article{0f76c203d3604915a32094ce6a3efd8d,

title = "A European multicentre photopatch test study",

abstract = "Background The two most common agent groups currently responsible for photoallergic contact dermatitis (PACD) are organic ultraviolet (UV) absorbers in sunscreens and topical nonsteroidal anti-inflammatory drugs (NSAIDs). However, availability of information on the photoallergenic potential of these agents is scarce. Objectives To obtain current information on the frequency of PACD to 19 organic UV absorbers and five topical NSAIDs, including newer agents, in common usage in Europe. Methods A prospective, multicentre photopatch test study was conducted with 1031 patients attending for investigation of suspected PACD in 30 centres across 12 European countries. Results A total of 346 PACD reactions in 200 (19·4%) subjects occurred. PACD was most commonly caused by the topical NSAIDs, ketoprofen (128 subjects) and etofenamate (59 subjects). Of the organic UV absorbers, octocrylene, benzophenone-3 and butyl methoxydibenzoylmethane most frequently elicited PACD. The 'newer' organic sunscreen absorbers rarely led to PACD. There appeared to be an association between the agents ketoprofen, octocrylene and benzophenone-3, with several subjects developing PACD to two or all three agents concomitantly. Allergic contact dermatitis (ACD) was less commonly observed than PACD, comprising 55 reactions in 47 (5%) subjects. Irritant reactions and photoaugmentation and photoinhibition of ACD occurred infrequently. Conclusions The European multicentre photopatch test study has provided current information on the relative frequency of PACD to common photoallergens. Such data will be of value when deciding on which agents to include in a future European 'baseline' photopatch test series. {\textcopyright} 2012 The Authors. BJD {\textcopyright} 2012 British Association of Dermatologists.",

author = "Kerr, {Alastair C.} and J. Ferguson and Ibbotson, {S. H.} and Dawe, {R. S.} and Haylett, {A. K.} and Rhodes, {L. E.} and H. Adamski and A. Alomar and E. Serra and C. Antoniou and F. Aubin and M. Vigan and T. Biedermann and J. Fischer and Bourrain, {J. L.} and D. Bruynzeel and T. Rustemeyer and Carrascosa, {J. M.} and Chowdhury, {M. M.U.} and {dela Cuadra}, J. and C. Foti and J. Gardeazabal and Gawkrodger, {D. J.} and A. Gimenez-Arnau and M. Goncalo and A. Goossens and M. Lecha and Marguery, {M. C.} and Neumann, {N. J.} and B. Niklasson and Peyron, {J. L.} and P. Pigatto and R. Spiewak and N. Stone and A. Tanew and P. Thomas and A. Bonnevalle and Wilkinson, {S. M.} and P. Wolf and A. Gruber-Wackernagel and Wulf, {H. C.}",

year = "2012",

month = may,

day = "1",

doi = "10.1111/j.1365-2133.2012.10857.x",

language = "English",

volume = "166",

pages = "1002--1009",

journal = "British Journal of Dermatology",

issn = "0007-0963",

number = "5",

}

Kerr, AC, Ferguson, J, Ibbotson, SH, Dawe, RS, Haylett, AK, Rhodes, LE, Adamski, H, Alomar, A, Serra, E, Antoniou, C, Aubin, F, Vigan, M, Biedermann, T, Fischer, J, Bourrain, JL, Bruynzeel, D, Rustemeyer, T, Carrascosa, JM, Chowdhury, MMU, dela Cuadra, J, Foti, C, Gardeazabal, J, Gawkrodger, DJ, Gimenez-Arnau, A, Goncalo, M, Goossens, A, Lecha, M, Marguery, MC, Neumann, NJ, Niklasson, B, Peyron, JL, Pigatto, P, Spiewak, R, Stone, N, Tanew, A, Thomas, P, Bonnevalle, A, Wilkinson, SM, Wolf, P, Gruber-Wackernagel, A & Wulf, HC 2012, 'A European multicentre photopatch test study', British Journal of Dermatology, vol. 166, no. 5, pp. 1002-1009. https://doi.org/10.1111/j.1365-2133.2012.10857.x

TY - JOUR

T1 - A European multicentre photopatch test study

AU - Kerr, Alastair C.

AU - Ferguson, J.

AU - Ibbotson, S. H.

AU - Dawe, R. S.

AU - Haylett, A. K.

AU - Rhodes, L. E.

AU - Adamski, H.

AU - Alomar, A.

AU - Serra, E.

AU - Antoniou, C.

AU - Aubin, F.

AU - Vigan, M.

AU - Biedermann, T.

AU - Fischer, J.

AU - Bourrain, J. L.

AU - Bruynzeel, D.

AU - Rustemeyer, T.

AU - Carrascosa, J. M.

AU - Chowdhury, M. M.U.

AU - dela Cuadra, J.

AU - Foti, C.

AU - Gardeazabal, J.

AU - Gawkrodger, D. J.

AU - Gimenez-Arnau, A.

AU - Goncalo, M.

AU - Goossens, A.

AU - Lecha, M.

AU - Marguery, M. C.

AU - Neumann, N. J.

AU - Niklasson, B.

AU - Peyron, J. L.

AU - Pigatto, P.

AU - Spiewak, R.

AU - Stone, N.

AU - Tanew, A.

AU - Thomas, P.

AU - Bonnevalle, A.

AU - Wilkinson, S. M.

AU - Wolf, P.

AU - Gruber-Wackernagel, A.

AU - Wulf, H. C.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Background The two most common agent groups currently responsible for photoallergic contact dermatitis (PACD) are organic ultraviolet (UV) absorbers in sunscreens and topical nonsteroidal anti-inflammatory drugs (NSAIDs). However, availability of information on the photoallergenic potential of these agents is scarce. Objectives To obtain current information on the frequency of PACD to 19 organic UV absorbers and five topical NSAIDs, including newer agents, in common usage in Europe. Methods A prospective, multicentre photopatch test study was conducted with 1031 patients attending for investigation of suspected PACD in 30 centres across 12 European countries. Results A total of 346 PACD reactions in 200 (19·4%) subjects occurred. PACD was most commonly caused by the topical NSAIDs, ketoprofen (128 subjects) and etofenamate (59 subjects). Of the organic UV absorbers, octocrylene, benzophenone-3 and butyl methoxydibenzoylmethane most frequently elicited PACD. The 'newer' organic sunscreen absorbers rarely led to PACD. There appeared to be an association between the agents ketoprofen, octocrylene and benzophenone-3, with several subjects developing PACD to two or all three agents concomitantly. Allergic contact dermatitis (ACD) was less commonly observed than PACD, comprising 55 reactions in 47 (5%) subjects. Irritant reactions and photoaugmentation and photoinhibition of ACD occurred infrequently. Conclusions The European multicentre photopatch test study has provided current information on the relative frequency of PACD to common photoallergens. Such data will be of value when deciding on which agents to include in a future European 'baseline' photopatch test series. © 2012 The Authors. BJD © 2012 British Association of Dermatologists.

AB - Background The two most common agent groups currently responsible for photoallergic contact dermatitis (PACD) are organic ultraviolet (UV) absorbers in sunscreens and topical nonsteroidal anti-inflammatory drugs (NSAIDs). However, availability of information on the photoallergenic potential of these agents is scarce. Objectives To obtain current information on the frequency of PACD to 19 organic UV absorbers and five topical NSAIDs, including newer agents, in common usage in Europe. Methods A prospective, multicentre photopatch test study was conducted with 1031 patients attending for investigation of suspected PACD in 30 centres across 12 European countries. Results A total of 346 PACD reactions in 200 (19·4%) subjects occurred. PACD was most commonly caused by the topical NSAIDs, ketoprofen (128 subjects) and etofenamate (59 subjects). Of the organic UV absorbers, octocrylene, benzophenone-3 and butyl methoxydibenzoylmethane most frequently elicited PACD. The 'newer' organic sunscreen absorbers rarely led to PACD. There appeared to be an association between the agents ketoprofen, octocrylene and benzophenone-3, with several subjects developing PACD to two or all three agents concomitantly. Allergic contact dermatitis (ACD) was less commonly observed than PACD, comprising 55 reactions in 47 (5%) subjects. Irritant reactions and photoaugmentation and photoinhibition of ACD occurred infrequently. Conclusions The European multicentre photopatch test study has provided current information on the relative frequency of PACD to common photoallergens. Such data will be of value when deciding on which agents to include in a future European 'baseline' photopatch test series. © 2012 The Authors. BJD © 2012 British Association of Dermatologists.

U2 - 10.1111/j.1365-2133.2012.10857.x

DO - 10.1111/j.1365-2133.2012.10857.x

M3 - Article

SN - 0007-0963

VL - 166

SP - 1002

EP - 1009

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 5

ER -

A European multicentre photopatch test study

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