Abstract
Objective: To determine the possible interaction between the antihypertensive agent cicletanine and the hypoglycaemic drug tolbutamide. Methods: Time-courses of glycaemia and serum immunoreactive insulin (IRI) were followed in 10 healthy subjects after two tolbutamide infusions in each volunteer: initially alone and 9 days later concomitantly with repeated oral cicletanine. any drug interaction was quantified on the basis of a decrease or increase in the AUC with time of glycaemia and IRI by subtraction of baseline concentration (AUC0240LY and corresponding time to peaks, were also assessed. Results: Following tolbutamide, mean AUC0240-GLY values were 97.7 and 98.8 mmol·l-1 min, without or with cicletanine, respectively; the corresponding AUC060-IRI were 485 and 321 mU·l-1·min. Mean peak glycaemia values were 0.996 and 1.071 mmol·l-1. Regarding the peak IRI, a decrease was observed after tolbutamide and cicletanine: median values were 29.2 and 17.4 mU·l-1. The corresponding median time to peak of glycaemia and IRI values were 30 and 30 min, and 5 (all subjects) and 5 min. Conclusion:: No clinically relevant interaction was shown after the concomitant administration of repeated oral doses of cicletanine and acute intravenous tolbutamide to healthy volunteers.
Original language | English |
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Pages (from-to) | 381-384 |
Journal | European Journal of Clinical Pharmacology |
Volume | 50 |
DOIs | |
Publication status | Published - 22 Jul 1996 |
Keywords
- Cicletanine
- Drug interaction
- Healthy volunteers
- Tolbutamide