A comprehensive review of the autoimmune pathogenesis of acquired hemophilia A

Jose Pardos-Gea; Jordi Barquinero; Iñaki Alvarez; Vicente Cortina; Iris Garcia Martínez; Laura Martín Fernández; Francisco Vidal

doi:10.1016/j.thromres.2025.109444

A comprehensive review of the autoimmune pathogenesis of acquired hemophilia A

Jose Pardos-Gea^*, Jordi Barquinero, Iñaki Alvarez, Vicente Cortina, Iris Garcia Martínez, Laura Martín Fernández, Francisco Vidal

^*Corresponding author for this work

Department of Cellular Biology, Physiology and Immunology

Research output: Contribution to journal › Review article › Research › peer-review

Abstract

Acquired haemophilia A (AHA) constitutes the most frequent form of autoimmunity againts coagulation factors. The pathogenic basis of anti-FVIII autoantibodies production remains unknown and our narrative review explores the possible causes and provides an overview of evidence data.

Original language	English
Article number	109444
Number of pages	9
Journal	Thrombosis Research
Volume	254
Early online date	Aug 2025
DOIs	https://doi.org/10.1016/j.thromres.2025.109444
Publication status	Published - Oct 2025

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10.1016/j.thromres.2025.109444Licence: C In Copyright

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title = "A comprehensive review of the autoimmune pathogenesis of acquired hemophilia A",

abstract = "Acquired haemophilia A (AHA) constitutes the most frequent form of autoimmunity againts coagulation factors. The pathogenic basis of anti-FVIII autoantibodies production remains unknown and our narrative review explores the possible causes and provides an overview of evidence data.",

keywords = "Acquired haemophilia, Anti-FVIII autoantibodies, Haemophilia",

author = "Jose Pardos-Gea and Jordi Barquinero and I{\~n}aki Alvarez and Vicente Cortina and Mart{\'i}nez, \{Iris Garcia\} and Fern{\'a}ndez, \{Laura Mart{\'i}n\} and Francisco Vidal",

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doi = "10.1016/j.thromres.2025.109444",

language = "English",

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T1 - A comprehensive review of the autoimmune pathogenesis of acquired hemophilia A

AU - Pardos-Gea, Jose

AU - Barquinero, Jordi

AU - Alvarez, Iñaki

AU - Cortina, Vicente

AU - Martínez, Iris Garcia

AU - Fernández, Laura Martín

AU - Vidal, Francisco

PY - 2025/10

Y1 - 2025/10

N2 - Acquired haemophilia A (AHA) constitutes the most frequent form of autoimmunity againts coagulation factors. The pathogenic basis of anti-FVIII autoantibodies production remains unknown and our narrative review explores the possible causes and provides an overview of evidence data.

AB - Acquired haemophilia A (AHA) constitutes the most frequent form of autoimmunity againts coagulation factors. The pathogenic basis of anti-FVIII autoantibodies production remains unknown and our narrative review explores the possible causes and provides an overview of evidence data.

KW - Acquired haemophilia

KW - Anti-FVIII autoantibodies

KW - Haemophilia

UR - https://www.scopus.com/pages/publications/105014542097

UR - https://www.mendeley.com/catalogue/3714aa53-9aef-352c-8905-0eb564f62df3/

UR - https://portalrecerca.uab.cat/en/publications/0983e52b-cd2b-44e2-b910-94f0373e5a30

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DO - 10.1016/j.thromres.2025.109444

M3 - Review article

C2 - 40886555

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SN - 0049-3848

VL - 254

JO - Thrombosis Research

JF - Thrombosis Research

M1 - 109444

ER -

A comprehensive review of the autoimmune pathogenesis of acquired hemophilia A

Abstract

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