A comparison between radiometric and fluorimetric methods for measuring SSAO activity

Alejandro Gella, Montse Solé, Irene Bolea, Mariacarla Ventriglia, Mariacristina Siotto, Nuria Durany, Rosanna Squitti, Mercedes Unzeta

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Semicarbazide-sensitive amine oxidase (SSAO) metabolizes the oxidative deamination of primary aromatic and aliphatic amines. The final cytotoxic products of its catalysis contribute to diseases involving vascular degeneration. The increasing interest in measuring SSAO activity has led to the development of several different methods. Herein, we compare SSAO activity results obtained with radiometric and fluorimetric methods in 49 plasma samples. Although not interchangeable, a significant correlation was obtained between methods. Considering these limitations, the fluorimetric method might replace the radioisotopic one. © 2013 Springer-Verlag Wien.
Original languageEnglish
Pages (from-to)1015-1018
JournalJournal of Neural Transmission
Volume120
Issue number6
DOIs
Publication statusPublished - 1 Jun 2013

Keywords

  • Biomarkers
  • Fluorimetric
  • Method comparison
  • Radiometric
  • Semicarbazide- sensitive amine oxidase

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