A compact miniaturized flow system based on low-temperature co-fired ceramic technology coupled to LED mini-photometer for determination of dipyrone in pharmaceutical formulations

Willian T. Suarez, Osmundo D. Pessoa-Neto, Vagner B. Dos Santos, Ana Rita De A. Nogueira, Ronaldo C. Faria, Orlando Fatibello-Filho, Julián A. Chamarro

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8 Citations (Scopus)

Abstract

In this work, an analytical microsystem based on LTCC (low-temperature co-fired ceramic) technology with monolithic incorporation of an optical flow cell for determination of dipyrone in pharmaceuticals is described. The detection system is based on the formation of a blue chromophore between dipyrone and Fe(III) photometrically monitored at 630 nm using a lab made LED mini photometer constructed with a light emitting diode as a radiation source and a Si photodiode as a detector. The lab-made mini-photometer elaborated presented a good performance in regard to high signal/noise ratio, low drift and good sensitivity. The analytical curve was linear in the dipyrone concentration range from 1.0 × 10-4 to 3.5 × 10-3 mol L-1, limit of detection of 4.5 × 10-5 mol L -1 and total time of analyses of 20 s yielding an analytical frequency of 195 h-1 with a low waste generation per analysis (480 μL). © 2013 Sociedade Brasileira de Química.
Original languageEnglish
Pages (from-to)847-855
JournalJournal of the Brazilian Chemical Society
Volume24
Issue number5
DOIs
Publication statusPublished - 20 Jun 2013

Keywords

  • Analytical microsystem
  • Dipyrone
  • Flow injection analysis
  • LED photometer
  • Low-temperature co-fired ceramic

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