TY - JOUR
T1 - A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function: Pre-Clinical Study in the Porcine Myocardial Infarction Model
AU - Perea-Gil, Isaac
AU - Prat-Vidal, Cristina
AU - Gálvez-Montón, Carolina
AU - Roura, Santiago
AU - Llucià-Valldeperas, Aida
AU - Soler-Botija, Carolina
AU - Iborra-Egea, Oriol
AU - Díaz-Güemes, Idoia
AU - Crisóstomo, Verónica
AU - Sánchez-Margallo, Francisco M.
AU - Bayes-Genis, Antoni
PY - 2016/8/1
Y1 - 2016/8/1
N2 - © 2016 The Authors Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, and promoted neovascularization of the ischemic myocardium. The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans.
AB - © 2016 The Authors Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, and promoted neovascularization of the ischemic myocardium. The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans.
KW - adipose tissue-derived progenitor cells
KW - cardiac tissue engineering
KW - decellularized myocardial scaffold
KW - myocardial infarction
KW - pre-clinical model
U2 - https://doi.org/10.1016/j.jacbts.2016.06.005
DO - https://doi.org/10.1016/j.jacbts.2016.06.005
M3 - Article
VL - 1
SP - 360
EP - 372
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
SN - 2452-302X
IS - 5
ER -
