A case of hyper-reactive malarial splenomegaly. The role of rapid antigen-detecting and PCR-based tests

B. Mothe, J. Lopez-Contreras*, O. H. Torres, C. Muñoz, P. Domingo, M. Gurgui

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Hyper-reactive malarial splenomegaly (HMS) - originally referred to as tropical splenomegaly syndrome - is characterized by a massive splenomegaly, high titres of anti-malarial antibodies and polyclonal IgM hypergammaglobulinemia. It is believed to be a consequence of an aberrant immunological response to prolonged exposure to malarial parasites. Although it is a frequent disease in the tropics, it is infrequent in western countries and is only seen in long-term residents from endemic areas. We describe the case of a 67-year-old Spanish man, a missionary in Cameroon for 30 years, who presented with a clinical history that fulfilled the diagnosis of HMS. We discuss the role and importance of PCR-based techniques in demonstrating lowgrade malarial parasitemia and the usefulness of new rapid antigen-detecting dipstick tests.

Original languageAmerican English
Pages (from-to)167-169
Number of pages3
JournalInfection
Volume36
Issue number2
DOIs
Publication statusPublished - Apr 2008

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