A care bundle approach for prevention of ventilator-associated pneumonia

J. Rello, E. Afonso, T. Lisboa, M. Ricart, B. Balsera, A. Rovira, J. Valles, E. Diaz

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)


Implementation of care bundles for prevention of ventilator-associated pneumonia (VAP) and its impact on patient outcomes requires validation with long-term follow-up. A collaborative multi-centre cohort study was conducted in five Spanish adult intensive-care units. A care bundle approach based on five measures was implemented after a 3-month baseline period, and compliance, VAP rates, intensive-care unit length of stay (ICU LOS) and duration of mechanical ventilation were prospectively recorded for 16months. There were 149 patients in the baseline period and 885 after the intervention. Compliance with all measures after intervention was <30% (264/885). In spite of this, VAP incidence decreased from 15.5% (23/149) to 11.7% (104/885), after the intervention (p <0.05). This reduction was significantly associated with hand hygiene (OR=0.35), intra-cuff pressure control (OR=0.21), oral hygiene (OR=0.23) and sedation control (OR=0.51). Use of the care bundle was associated with an incidence risk ratio of VAP of 0.78 (95% CI 0.15-0.99). We documented a reduction of median ICU LOS (from 10 to 6days) and duration of mechanical ventilation (from 8 to 4days) for patients with full bundle compliance (intervention period). Efforts on VAP prevention and outcome improvement should focus on achieving higher compliance in hand and oral hygiene, sedation protocols and intracuff pressure control. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
Original languageEnglish
Pages (from-to)363-369
JournalClinical Microbiology and Infection
Issue number4
Publication statusPublished - 1 Jan 2013


  • Care bundles
  • Intensive-care unit outcomes
  • Patient safety
  • Respiratory care
  • Ventilator-associated pneumonia prevention


Dive into the research topics of 'A care bundle approach for prevention of ventilator-associated pneumonia'. Together they form a unique fingerprint.

Cite this