A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy

J. L. Muñoz-Gómez, E. Monteagudo, V. Lloveras, T. Parella, J. Veciana, J. Vidal-Gancedo

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

© The Royal Society of Chemistry 2015. The synthesis, structural characterization and the successful application of a carbon centered radical derived from 1,3-bisdiphenylene-2-phenylallyl (BDPA), its benzyl alcohol derivative (BA-BDPA), as a polarizing agent for Dynamic Nuclear Polarization (DNP) are described. The reported BA-BDPA radical meets all the requirements to become a promising candidate for its use in in vivo DNP-NMR experiments: it is soluble in neat [1-13C]pyruvic acid, insoluble in the dissolution transfer solvent and is effective as a polarizing agent in fast dissolution DNP-NMR applications, without the need for using glassing agents. Moreover, it enables a simple but effective in-line radical filtration to obtain hyperpolarized solutions of [1-13C]pyruvic acid free of radicals that offers a better polarization performance. This journal is
Original languageEnglish
Pages (from-to)2689-2693
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number9
DOIs
Publication statusPublished - 7 Mar 2015

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