5,5-Diethylbarbiturate tubular electrode for use in flow-injection detection systems

José L.F.C. Lima, M. Conceição B.S.M. Montenegro, J. Alonso, J. Bartroli, J. G. Raurich

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19 Citations (Scopus)


The construction, assessment and pharmaceutical appalications of a tubular potentiometric detector sensitive to the 5,5-diethylbarbiturate anion based on quaternary ammonium salt (tetraoctylammonium5,5-diethylbarbiturate) dissolved in o-nitrophenyl octyl ether immobilized in PVC are described. The intrinsic characteristics of the tubular electrode were determined in a low-dispersion manifold and compared with those of a conventional-shaped electrode with no internal reference solution and incorporating the same sensor. The behaviour of a double-channel flow-injection manifold with the same potentiometric detector was evaluated to assess its applicability to the determination of 5,5-diethylbarbiturate in pharmaceutical preparations. Data obtained in the determination of the anion in the latter matrices are presented and compared with those obtained by the conventional British Pharmacopoeia method. © 1990.
Original languageEnglish
Pages (from-to)221-225
JournalAnalytica Chimica Acta
Issue numberC
Publication statusPublished - 1 Jan 1990


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