TY - JOUR
T1 - 3R coordination by Fanconi anemia proteins
AU - Macé, Gaëtane
AU - Bogliolo, Massimo
AU - Guervilly, Jean-Hugues
AU - Villard, Jean Antoine Dugas du
AU - Rosselli, Filippo
PY - 2005/7
Y1 - 2005/7
N2 - Fanconi anemia (FA) is a recessive cancer prone syndrome featuring bone marrow failure and hypersensitivity to DNA crosslinks. Nine FA genes have been isolated so far. The biochemical function(s) of the FA proteins remain(s) poorly determined. However, a large consensus exists on the evidence that, to cope with DNA cross-links, a cell needs a functional FA pathway. In this review, we resume current understanding of how the FA pathway works in response to DNA damage and how it is integrated in a complex network of proteins involved in the maintenance of the genetic stability.
AB - Fanconi anemia (FA) is a recessive cancer prone syndrome featuring bone marrow failure and hypersensitivity to DNA crosslinks. Nine FA genes have been isolated so far. The biochemical function(s) of the FA proteins remain(s) poorly determined. However, a large consensus exists on the evidence that, to cope with DNA cross-links, a cell needs a functional FA pathway. In this review, we resume current understanding of how the FA pathway works in response to DNA damage and how it is integrated in a complex network of proteins involved in the maintenance of the genetic stability.
U2 - 10.1016/j.biochi.2005.05.003
DO - 10.1016/j.biochi.2005.05.003
M3 - Article
VL - 87
SP - 647
EP - 658
JO - Biochimie
JF - Biochimie
IS - 7
ER -
