TY - JOUR
T1 - 3 TESLA MR imaging in adults with focal onset epilepsy
AU - Toledo, Manuel
AU - Sarria-Estrada, Silvana
AU - Quintana, Manuel
AU - Auger, Cristina
AU - Salas-Puig, Xavier
AU - Santamarina, Estevo
AU - Vert, Carla
AU - Rovira, Alex
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Objective The finding of cerebral epileptogenic lesions in magnetic resonance (MR) has demonstrated to be a relevant prognostic factor for potential surgical candidates. In a series of consecutive adults with focal onset epilepsy, we investigated the yield of 3 T MR imaging for detecting epileptogenic cerebral lesions. Materials and methods We prospectively recruited 161 adult patients with a diagnosis of focal epilepsy, all of whom underwent standardized MR imaging study performed with a 3 T magnet. Results Lesion-related epilepsy was observed in 48% of patients, and 12% of cryptogenic patients showed subtle or non-specific lesions related to the epileptogenic source. The most common findings were focal cortical dysplasia and vascular lesions, followed by mesial temporal sclerosis, tumors, and scars from previous cerebral injuries. Patients older than 72 years were more likely to have vascular epilepsy. Conclusions Diagnostic assessment using a standardized 3 T MR imaging protocol for focal-onset epilepsy detects lesions in nearly half the patients. Our results indicate that elders with focal epilepsy should be searched for vascular lesions. © 2013 Elsevier B.V.
AB - Objective The finding of cerebral epileptogenic lesions in magnetic resonance (MR) has demonstrated to be a relevant prognostic factor for potential surgical candidates. In a series of consecutive adults with focal onset epilepsy, we investigated the yield of 3 T MR imaging for detecting epileptogenic cerebral lesions. Materials and methods We prospectively recruited 161 adult patients with a diagnosis of focal epilepsy, all of whom underwent standardized MR imaging study performed with a 3 T magnet. Results Lesion-related epilepsy was observed in 48% of patients, and 12% of cryptogenic patients showed subtle or non-specific lesions related to the epileptogenic source. The most common findings were focal cortical dysplasia and vascular lesions, followed by mesial temporal sclerosis, tumors, and scars from previous cerebral injuries. Patients older than 72 years were more likely to have vascular epilepsy. Conclusions Diagnostic assessment using a standardized 3 T MR imaging protocol for focal-onset epilepsy detects lesions in nearly half the patients. Our results indicate that elders with focal epilepsy should be searched for vascular lesions. © 2013 Elsevier B.V.
KW - Arterial spin labeling
KW - Epilepsy
KW - Magnetic resonance
KW - Seizures
KW - Vascular epilepsy
U2 - 10.1016/j.clineuro.2013.07.039
DO - 10.1016/j.clineuro.2013.07.039
M3 - Article
VL - 115
SP - 2111
EP - 2116
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
SN - 0303-8467
IS - 10
ER -