β5 integrin is the major contributor to the α v integrin-mediated blockade of HIV-1 replication

Ester Ballana, Eduardo Pauls, Bonaventura Clotet, Françoise Perron-Sierra, Gordon C. Tucker, José A. Esté

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Monocytes and macrophages are targets of HIV-1 infection and play critical roles in multiple aspects of viral pathogenesis. During the differentiation of monocytes to macrophages, adhesion molecules such as integrins are upregulated; therefore, they provide signals that control the process and subsequently may render macrophages more susceptible to HIV-1 infection. Previous work demonstrated that blocking α v-containing integrins triggered a signal transduction pathway leading to the inhibition of NF-κB-dependent HIV-1 transcription. In this paper, we show the influence of the different α v-coupled β integrins in HIV-1 replication in macrophages. Inhibition of β integrins, either by specific mAbs, small arginine-glycine-aspartic acid (RGD) mimetic compounds, or RNA interference, showed that integrin β 5 was the major contributor to the integrin-mediated blockade of HIV-1 replication. Importantly, such inhibition did not induce changes in cell adhesion to the substrate. In conclusion, our results reveal a significant role of the integrin dimmer α vβ 5 in HIV-1 infection of macrophages. Copyright©2010 by The American Association of Immunologists, Inc.
Original languageEnglish
Pages (from-to)464-470
JournalJournal of Immunology
Volume186
Issue number1
DOIs
Publication statusPublished - 1 Jan 2011

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