ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart

Alexander M. Lewis, Parvinder K. Aley, Ali Roomi, Justyn M. Thomas, Roser Masgrau, Clive Garnham, Katherine Shipman, Claire Paramore, Duncan Bloor-Young, Luke E.L. Sanders, Derek A. Terrar, Antony Galione, Grant C. Churchill

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18 Citations (Scopus)

Abstract

Evidence suggests that ß-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca 2+-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of these messengers requires direct measurements of their levels in response to receptor stimulation. Here we report that in intact Langendorff-perfused hearts ß-adrenergic stimulation increased both messengers, with NAADP being transient and cADPR being sustained. Both NAADP and cADPR have physiological and therefore pathological relevance by providing alternative drug targets in the ß-adrenergic receptor signaling pathway. © 2012 Elsevier Inc.
Original languageEnglish
Pages (from-to)326-329
JournalBiochemical and Biophysical Research Communications
Volume427
DOIs
Publication statusPublished - 19 Oct 2012

Keywords

  • Calcium
  • Cyclic ADP-ribose
  • Heart
  • Nicotinic acid adenine dinucleotide phosphate
  • ß-Adrenergic receptor

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    Lewis, A. M., Aley, P. K., Roomi, A., Thomas, J. M., Masgrau, R., Garnham, C., Shipman, K., Paramore, C., Bloor-Young, D., Sanders, L. E. L., Terrar, D. A., Galione, A., & Churchill, G. C. (2012). ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart. Biochemical and Biophysical Research Communications, 427, 326-329. https://doi.org/10.1016/j.bbrc.2012.09.054