Abstract
Evidence suggests that ß-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca 2+-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of these messengers requires direct measurements of their levels in response to receptor stimulation. Here we report that in intact Langendorff-perfused hearts ß-adrenergic stimulation increased both messengers, with NAADP being transient and cADPR being sustained. Both NAADP and cADPR have physiological and therefore pathological relevance by providing alternative drug targets in the ß-adrenergic receptor signaling pathway. © 2012 Elsevier Inc.
Original language | English |
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Pages (from-to) | 326-329 |
Number of pages | 2 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 427 |
DOIs | |
Publication status | Published - 19 Oct 2012 |
Keywords
- Calcium
- Cyclic ADP-ribose
- Heart
- Nicotinic acid adenine dinucleotide phosphate
- ß-Adrenergic receptor