Teloreme instability and the formation and transmission of radiation induced DNA damage - TELORAD

  • Genescà, A. (Principal Investigator)
  • Tusell Padros, Laura (Scholar)
  • Martin Flix, Marta (Investigator)
  • Mr Mombela Cano (Investigator)
  • Mr Syrota (Investigator)
  • Mr. Schimd (Investigator)
  • Ms Macfarlane (Investigator)
  • Ponsa Arjona, Immaculada (Investigator)
  • RIVA, Silvano (Investigator)
  • VILLAVERDE, Fernando (Investigator)

Project Details

Description

The new insights in telomere maintenance and telomerase activity as keypoints in tumour. The increased knowledge in induction and repair of DNA damage have raised large concern in the link between two process. TELORAD aims to determine the mechanistic link between telomerase, telomere binding protein and DNA repair gene and their respective role in the radiosensitivity. Mechanisms of stabilisation of the broken end, start point to the transmission of the radiation induced damage will be studied. Long term consequences as gene amplification and chromosome imbalance will be researched to identify the involvement of telomere maintenance in Hypersensitivity of individuals.
StatusFinished
Effective start/end date1/02/0031/01/03

Collaborative partners

  • Universitat Autònoma de Barcelona (UAB)
  • Spanish National Research Council (CSIC) (Associate)
  • Commissariat à l'énergie atomique et aux énergies alternatives (CEA) (Coordinator) (lead)
  • University of Pavia (UNIPV) (Associate)
  • Brunel University London (Associate)
  • National Research Council of Italy (Associate)
  • Fundación Centro Oncológico de Galicia "José Antonio Quiroga y Piñeyro" (Associate)

Funding

  • European Commission (EC): €540,479.00

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