Vasculogenesis and angiogenesis are increased in many diseases, and diabetes is a dramatic paradigm for its social impact. During the last years, a high number of experimental animal models have been genetically engineered to analyse the molecular mechanisms involved in the formation of vascular system. Nevertheless, it has not been over expressed IGF-I, an important inducer of neovascularization, in eye and kidney. This fact determines the aim of our study, including the examination of vasculogenesis and angiogenesis in the embryonary retina of IGF-I transgenic mice and in the kidney of avian embryos transfected with adenovirus transferring IGF-I gene. Another aspect of this study deals with the modulation of the expression and synthesis of VEGF. VEGF receptors, ephrines and Eph receptors by IGF-I. We are now publishing our first results in which we demonstrate that angiogenesis is altered in transgenic mice overespressing IGF-I. The study of vasculogenesis and angiogenesis in both, mice and avian embryos over expressing IGF-I, will allows the characterization of two new models to test the activity of potential antiantigenic drugs to control diabetic retinopathy and nephropathy.
|Effective start/end date||29/11/03 → 28/11/06|
- Instituto de Salud "Carlos III": €97,635.00