Síntesis estereoselectiva de productos naturales y análogos farmacológicamente activos

The main purpose of this project is the stereoselective total synthesis of biologically active natural products and their analogue. Target-oriented strategies have been designed for some of them (polycyclic alkaloids of the \i Securinega and Stemona\i0 groups, cyclobutanic pheromones, anemonin, sceptrine), diversity-oriented synthesis for other (gabosines and analogues, nucleoside analogues, molecular switchers) and structure-based approached for a third group (antitumoral cyclohexane derivates). We plan also to study synthetic methodologies related to some key steps of the designed routes. In particular, we intend to study the formation of cyclobutanes through photoactivated reactions, as well as Lewis acid mediated catalytic processes. In the former case, a substrate -based steroselectivity control will apply (generally by using chiral \alpha, \beta- unsaturated lactones and lactams) and in the last case by using metal complex of chiral ligands. We also pretend to study the stereoselective formation of polysubstituted pyrans by photoactivated radicalary alkylation of \alpha, \beta- unsaturated lactones and lactams