Síntesis altament estereoselectives de productes biorgànics a partir de gamma-lactones homoquirals

This project deals with the use of simple unsaturated "gama"-lactones as synthons in the preparation of complex molecules of biologycal interest. In many cases, the key step of the synthetic pathway is a cycloaddition reaction (photochemical [2+2], 1,3-dipolar [3+2], Diels-Alder [4+2]) and therefore these reactions will be deeply investigated. Some of the target compounds are alfa-hydroxy-beta-aminoacids, "Sekurinega" and "Stemona" alkaloids, alfa-hydroxyprotoanemonin, "cis"-anemonin, etc. The use of homochiral "gama"-lactones will permit the access to these compounds in a stereoslective approach.