Síntesi enantioselectiva d'aminoàcids i nucleòsids conformacionalment restringits, i altres compostos carbocíclics relacionats

Project Details


The main objective of this project is the enantio- and diastereoselecive synthesis of cyclopropane aminoacids and nucleosides as well as of other related carbocyclic compounds including cyclopentane and cyclohexane derivatives. The key step step for the production of the ring and for the creation and control of the stereogenic centers in these synthetic approaches involves 1,3-dipolar cycloadditions of diazomethane and Diels-Alder reactions of convenient dienes, using enantiopure dipolarophiles and dienophiles obtained from D-gliceraldehyde as a chirality source. The stereocontrolled transformations of the obtained adducts must allow the development of highly efficient and versatile synthetic methodologies leading to manifold families of carbocyclic aminoacids and nucleosides. These works will be sustained by theoretical studies as an essential tool for understanding the factors that inf
Effective start/end date1/07/951/07/98


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