The aim of this work is the synthesis and biological evaluation of a new series of organic compounds allenic and acetylenic derivatives of indol-alkylamines, designed as monoamine-axidase inhibitors, the enzyme involved in the metabolism of some biogenic amines with neurotransmitter function closely related to depression. The structure-activity relationship obtained will allow us to establish the responsability of these compounds as antidepressives.
|Effective start/end date
|1/01/93 → 31/12/95
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