Síntesi de nous derivats de les indoquilamines i estudi de la relació estructura-activitat com a inhibidors de l'enzim monoamina-oxidasa

Project Details


The aim of this work is the synthesis and biological evaluation of a new series of organic compounds allenic and acetylenic derivatives of indol-alkylamines, designed as monoamine-axidase inhibitors, the enzyme involved in the metabolism of some biogenic amines with neurotransmitter function closely related to depression. The structure-activity relationship obtained will allow us to establish the responsability of these compounds as antidepressives.
Effective start/end date1/01/9331/12/95


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