Síntesi de nous derivats de les indoquilamines i estudi de la relació estructura-activitat com a inhibidors de l'enzim monoamina-oxidasa

  • Unzeta Lopez, Mercedes (Principal Investigator)
  • Gratacòs Ballescà, Elena (Investigator)
  • Lizcano de Vega, Jose Miguel (Investigator)
  • Sabrià Pau, Josefa (Investigator)

Project Details

Description

The aim of this work is the synthesis and biological evaluation of a new series of organic compounds allenic and acetylenic derivatives of indol-alkylamines, designed as monoamine-axidase inhibitors, the enzyme involved in the metabolism of some biogenic amines with neurotransmitter function closely related to depression. The structure-activity relationship obtained will allow us to establish the responsability of these compounds as antidepressives.
StatusFinished
Effective start/end date1/01/9331/12/95

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