Regulació de la inflamació cerebral pel sistema neuronal noradrenèrgic

Project Details


Brain inflammation contributes to a wide array of pathologies including multiple sclerosis, ischemia, or Alzheimer's disease. The key idea of this proposal is that brain inflammation is regulates-generally inhibited-by neuronal systems. This implies that the brain has endogenous mechanisms of protection against inflammatory processes. And that the dysregulation of these mechanisms may contribute to inflammatory damage. The general goal of this proposal is to study the regulation of brain inflammation by the noradrenergic system originated in the locus coeruleus. To this aim, we propose to use a comprehensive approach that includes studies in the whole animal as well as analysis o cellular and molecular mechanisms in cultures. The objectives are: -To determine if the glia and the brain endothelium are cellular targets of the anti-inflammatory and neuroprotective actions of noradrenaline. -To determine the role of glial trophic factors like the basic fibroblast growth factor, FGF2, in the actions of noradrenaline. -To determine the anti-inflammatory role of central noradrenaline in a model of brain inflammation produced by system administration of bacterial endotoxins
Effective start/end date13/12/0413/12/07


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