Regulació de la formació d'òxid nítric i de GMP cíclic en cèl.lules cerebel.loses

  • García Sánchez, Maria Carme Agustina (Principal Investigator)
  • Sardón Urtiaga, Teresa (Scholar)
  • Agulló Rueda, Luis (Investigator)
  • Baltrons Soler, Maria Antonia (Investigator)

Project Details


In the CNS, nitric oxide (NO) acts as an atypical neurotransmitter implicated among other functions in the development and stabilization of synaptic connections. The most common molecular target of NO is the soluble guanylyl cyclase. The cerebellum is the brain region with the highest activity of calcium-dependant NO synthase (cNOS), both in neurons and in astrocytes. Additionally, a calcium-independent NOS (iNOS) can be induced in both cell types. NO seems to participate in importants aspects of cerebellar development and both NO and cyclic GMP (cGMP) modulate, if astroglia is present, the process of long term depression (LTD) that is related to motor learning. Recent data from our laboratory indicates that the regulation of these activities and that of the metabolism of cGMP differs in both cell types. In the present project we propose the use of cultures of cerebellar granule cells an
Effective start/end date1/07/951/07/98


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