Quantificació sistemàtica i modelització de xarxes de fluxos metabòlics utilitzant isòtops estables i ressonància magnètica nuclear. Integració amb altres plataformes analítiques de genòmica i proteòm

Project Details

Description

The main purpose of this project is the stereoselective total synthesis of natural products having any interesting biological activity or their analogues. Starting materials are mostly a,ß-unsaturated carbonyl compounds, particularly lactones, ester and p-benzoquine acetals. We also study in depth the reactivity of these substrates, with the aim of broadening their synthetic versatility. The target molecules are the Securinega and Stemona families of alkaloids, several polyfunctionalised cyclohexanes with known or potencial antibiotic and antitumoral activity (among other), cyclobutanic pheromones and nucleoside analogues. A large part of these compounds are polycyclic themselves and other may derive from polycyclic precursors. Therefore, key reactions include 1,3-dipolar cycloadditions, photochemical [2+2] cycloadditions, ring closing metathesis and radical cyclisations
StatusFinished
Effective start/end date1/10/0430/09/05

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