Proteoglycans (PGs) are essential components of the extracellular matrix (ECM) that are involved in cell adhesion, migration and differentiation. Their expression or structure is frequently altered in tumors, contributing to the anormal cell growth and metastasis. Our group is interested in two cell models able to differentiate "in vitro": the human melanoma (and other neuroectodermic derived tumors) and the colon carcinoma. In both cell types, it has been described that PGs have an important role in tumor development as well as in the morphogenesis and function of the normal tissue. Recently, we have identified a novel PG from melanoma, also present in astrocitoma and neuroblastoma, potently induced by TGF-B and which we have named PG-L. The main goals of this project are: a) purification and structural and functional characterization of PG-L; b) characterization of the PGs produced by
|Effective start/end date||20/05/94 → 20/05/96|
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