Knowledge about the role of protein phosphatases in the biology of yeast is rather scarce, although available data suggest that these enzymes perform key functions in the cell. The main goal of our project is to understand the role of phosphatases in yeast, taking advantage of yeast features as a tool for genetic manipulation and our experience in the control of metabolism by phosphorylation-dephosphorylation reactions. Essentially, our goals are: a) to isolate and characterize "S. cerevisiae" genes encoding putative protein phosphatases and to study the effects ofover expression and supression of the genes in the biology of yeast; b) to study the control of glycogen accumulation in yeast by cloning, expression and generation of mutations at specific phosphorylation sites of the glycogen synthase gene. Since glycogen metabolism is controlled by phosphorylation-dephosphorylation reactions
|Effective start/end date||2/08/90 → 2/08/93|
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