The development of treatments applicable to Alzheimer's disease and other age-related dementias represents a serious challenge for biomedical research. Several biological-neurochemical mechanisms have been proposed as putative causes, including cholinergic disfunction, glutamate disfunction, altered GABAergic transmission and autoinmunity processes. At present, none of them can explain age-related impairments and nodefinitive therapy is available. We propose a preventive approach to the problem by using procedures which animal research has demonstrated to be useful. Thus, several infantile stimulation procedures have showed a consistent capability to prevent or significantly delay age-related impairments in animals, as well as some parallel biological processes.
|Effective start/end date||30/05/91 → 30/05/94|