Precision PathoBiology for Disease Models

  • Ruberte Paris, Jesus (Principal Investigator)
  • Berth Mohr (Investigator)
  • Dr. Colin McKerlie (Investigator)
  • Dr. Illaria Bellantuono (Investigator)
  • Dr. Jean-Luc Sardou (Investigator)
  • Dr. Jithin Jose (Investigator)
  • Dr. Karen Svenson (Investigator)
  • Dr. Marcel Gyger (Investigator)
  • Dr. Martina Crispo (Investigator)
  • Dr. Patrick Sharp (Investigator)
  • Dr. Yann Herault (Investigator)
  • Prof. Cord Brakebusch (Investigator)
  • Prof. Dr. Dr. h.c. Martin Hrabé de Angelis (Investigator)
  • Prof. Fabio Mamano (Investigator)
  • Prof. Fuad A. Iraqi (Investigator)
  • Prof. Je Kung Seong (Investigator)
  • Prof. Luísa Mendes-Jorge (Investigator)
  • Prof. Martin Hrabé de Angelis (Investigator)
  • Prof. Paolo De Girolamo (Investigator)
  • Prof. Patrocinio Vergara (Investigator)
  • Prof. Paul Shofield (Investigator)
  • Prof. Radislav Sedlacek (Investigator)
  • Prof. Steve Brown (Investigator)

Project Details


Mouse-based studies are essential for all Precision Medicine Initiatives (PMIs), which aim to transform current medical practice to personalized healthcare. Global PMIs will combine tens-of-thousands of human individual genetic profiles, deep phenotyping, and environmental exposures and life style behaviors to guide therapies more targeted and cost-effective than current ¿one-size-fits-all¿ strategies. Mouse models will be needed to provide efficient and accurate assessment of the scientific validity of such gene-environment correlations. Furthermore, the success of using genetically engineered mice to evaluate genetic disease hypotheses has encouraged the development of large-scale European and global projects making the mouse the most used animal model. However, the scientific community lacks sufficient human resources and expertise in mouse pathology to effectively and reproducibly characterize and validate these animal models. Despite this increasing demand for mouse experts, there is a proven significant deficiency of specialised training opportunities for veterinary and medical pathologists and biomedical researchers to acquire the necessary expertise, especially formalized and recognized programs in Higher Education. In this scenario, no single European University has all the expertise, resources and personnel required to design and establish a strong educational program in Mouse Precision Pathobiology. For this reason several universities, research institution and companies have come together to establish PATHBIO, a Knowledge Alliance initiative, to develop a Virtual Learning Platform with innovative teaching material and to organize and deliver intensive specialized courses in Mouse Precision Pathobiology. The PATHBIO project also aims to design a Joint European Master Degree. The new degree program aims to become a benchmark Master qualification internationally in Mouse Precision Pathobiology.
Effective start/end date1/01/1931/12/21

Collaborative partners

  • (lead)
  • University of Cape Town
  • Toronto Center for Phenogenomics Inc.
  • The University of Sheffield
  • Charles River Laboratories Inc
  • Fujifilm Visualsonics Netherlands
  • The Jackson Laboratory
  • Federation of European Laboratory Animal Science Associations (FELASA)
  • Institut Pasteur de Montevideo
  • Australian Phenomics Network
  • Institut Clinique de la Souris
  • University of Copenhagen - Koslashbenhavns universitet
  • E. Mouse Phenotyping and archiving research infrastructure GmbH
  • Istituto di Biologia Cellulare e Neurobiologia
  • Tel Aviv University
  • Korea Mouse Phenotype Center
  • Universidade de Lisboa
  • Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
  • Università degli Studi di Napoli Federico II (UNINA)
  • International Council for Laboratory Animal Science
  • The Chancellor, Masters and Scholars of the University of Cambridge
  • Institute of Molecular Genetics AS CR
  • Harwell Institute- Medical Research Council


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