Main goal of therapeutic approaches towards Parkinson's disease is based in dopamine receptor activation. Clinical studies have demonstrated that after Levodopa treatment a dioskinetid side effect and a time-dependent decrease in the therapeutic effects has been observed. Dopamine D\sub 3\nosub receptor agonists (like pramipexole) show significant antiparkinsonian effects and their potential therapeutic interest has been suggested. On the other hand, the role of neuropeptides on the modulation of dopamine receptors has been made clear by recent data, emphasizing the importance of these findings for the improvement of the therapeutic strategy towards Parkinson's disease. The purpose of the present project is to study the effect of different neuropeptides on the modulation of D\sub 2/3\nosub dopamine receptors from functional point of view by studying the modulation of neurotransmitter release.
|Effective start/end date||1/07/98 → 1/07/99|
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