ATP and NPY can be released together with noradrenaline in most of the adrenergic synapsis, including blood vessels. These co-transmitters can modify not only postjunctional responses but also the prejunctional modulation of neurotransmitter release. It has also been reported in several models of experimental hipertension that central and peripheral adrenergic neurotransmission is modified. In addition, a different role of co-transmision has beensuggested for SHR when compared to WKY rats. Our purpose is to study: a) The ifluence of ATP and NPY either in a1-adrenoceptor (inositol phosphate accumulation) or a2-adrenoceptor (noradrenaline release modulation) mediated neurotransmision in the CNS from SHR and WKY rats, b) to study the role of both co-transmitters on functional, biochemical (inositol phosphate fromation) and electrophysiological (EJPs) a1-adrenoceptor mediated responses in se
|Effective start/end date||7/06/96 → 7/06/99|
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