Origen patern de gonosomopaties: estudi citogenètic i molecular de l'espermatozoide

  • Templado Meseguer, Cristina (Principal Investigator)

    Project Details


    Gonosomaties, sex chromosome abnormalities, are the most commonly chromosome aberrations in humans (Jacobs et al. , 1989). Most of studies in gonosomopaties have been realized in somatic cells from liver birth and spontaneous abortion surveys. However, only an indirect information about the etiology and risk in the offspring have been obtained from somatic studies because mechanisms that origin the chromosome abnormalities take out during the production of gametes. Turner syndrome (45 X) (79%) (Hassold et al., 1992) and Klinefelter syndrome (47 XXY) (50%) (Jacobs et al., 1988) are the gonosomopaties showing highest incidence of paternal origin, to difference the most of gonosomopaties showing a maternal origin. In the last years, direct analyses of human sperm chromosomes have been possible thanks to description of a method of human sperm-zona free hamster egg fusion (Martin et al., 1983
    Effective start/end date31/05/9331/12/96


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