Ant psychotic agents act on central dopaminergic and alpha-adrenergic receptors. Chronic administration of these drugs leads to dopamine and alfa-adrenergic receptor super sensitivity, effect that could explain some side effects which appear after chronic treatment. There is not clear evidence that dopamine is a transmitter on the peripheral nervous system. Nevertheless it has been accepted that pre and postsynaptic dopamine receptors are located in several peripheral tissues. This observation means that long-term neuoleptic drug administration could induce some modifications on peripheral dopamine and alpha-adrenergic receptors leading to functional changes, specially at cardiovascular level. In spite of its importance only a little information 1exist about peripheral actions after chronic neuroleptic drug administration. The main purpose of this study is to evaluate systematically the possible biochemical and functional modifications on peripheral catecholamine receptors induced by chronic neuroleptic drug administration
|Effective start/end date||1/01/88 → 31/12/88|
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