Metabolisme de l'àcid arquidònic en teixits d'hirudinea

  • Cañete Soler, Rafaela (Principal Investigator)
  • Bonet Marull, Sergi (Investigator)

    Project Details

    Description

    Leeches have been used as therapeutic agents for hundreds of years. Their ability to ingest and store blood in a liquid form has suggested the presence of powerful anti-hemostatic agents in their salivary glands and digestive system. Recently, various anticoagulants, fibrinolitic agents and protease inhibitors have been identified from several species of leeches. Eicosanoid is the generic term which refers to lipoxigenase andcyclooxigenase products of arachidonic acid metabolism and some of these metabolites are specifically involved in the physiology and pathophysiology of the vascular system. Although the arachidonic acid is one of the major phospholipid components of some Hirudinea, there is little information on the metabolism of the arachidonic acid in this group of invertebrates. It seems likely that some of its metabolites could be involved in the antihemostatic and antimetastasic
    StatusFinished
    Effective start/end date2/08/902/08/92

    Funding

    • Dirección General de Investigación Científica y Técnica (DGICYT): €24,040.48

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