Mecanismes cel·lulars de les respostes vasculars als agonistes alpha-adrenèrgics i al Neuropèptid Y en la rata normotense i hipertensa

  • Vila Calsina, Elisabet (Principal Investigator)
  • Vivas Sabido, Nuria María (Researcher on contract)
  • Sallés Alvira, Joan (Researcher on contract)

    Project Details


    Neuropeptide Y can act directly as a vasoconstrictor on certain vascular beds, and indirectly by potentiating the blood pressure response to alpha 2 and alpha 1 adrenoceptor agonists. In order to discover the cellular mechanisms involved in both processes we propose to investigate in blood vessels of normotensive and hypertensive rats: a) the effect of Neuropeptide Y on phosphatidyl inositol hydrolysis and on AMP-c accumulation and b) the influence of Neuropeptide Y on the second messenger responses induced by stimulation of vascular alpha 1 and alpha 2 adrenoceptors
    Effective start/end date1/04/9031/03/91


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