Neuropeptide Y can act directly as a vasoconstrictor on certain vascular beds, and indirectly by potentiating the blood pressure response to alpha 2 and alpha 1 adrenoceptor agonists. In order to discover the cellular mechanisms involved in both processes we propose to investigate in blood vessels of normotensive and hypertensive rats: a) the effect of Neuropeptide Y on phosphatidyl inositol hydrolysis and on AMP-c accumulation and b) the influence of Neuropeptide Y on the second messenger responses induced by stimulation of vascular alpha 1 and alpha 2 adrenoceptors
|Effective start/end date||1/04/90 → 31/03/91|
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