La reactivitat dels anells (Pt2S2) en composts [L2Pt(mu-S)2PtL2] front agents electròfils molt diversos. Síntesi recombinant, anàlisi del contingut metàl·lica i possible funció de MT

  • González Duarte, Pilar (Principal Investigator)
  • Mas Balleste, Ruben (Scholar)
  • Novio Vazquez, Fernando (Scholar)
  • Serra Batiste, Montserrat (Scholar)

Project Details

Description

The main objective of this project is to extend the limits in the two current research areas of the group on the basis of the results obtained in the present project (BQU2001-1976) and on the indications withdrawn from the literature. Thus, we aim at increasing knowledge on the chemical processes that arise from the high nucleophilicity of the sulfur atoms of the {Pt2S2} core in compounds of general formula [L2Pt(m?S)2PtL2]. For L2 = diphosphine (dppe, dppp), experimental and theoretical work will be addressed to analyze the ability of the {Pt2S2} ring to break the C-F bond, to heterolitically activate H2, to bind non metallic Lewis acids such as boron halides, BX3, and to behave as building block units in macromolecular structures of formula [(Pt2S2)m{L2Pt(m?S)2PtL2}n]. Moreover, the redox properties of the mentioned ring will be studied electrochemically, as well as its influence on the reactivity of the {Pt(cod)} fragment in complexes containing the [{Pt2S2}Pt(cod)] unit. The chemistry of [L2Pt(m?S)2PtL2] compounds will be correlated with that involved in the hydrodesulfurization process (HDS). For L2 = diarsine (dpae), the behavior of the {Pt2S2} core as precursor of high nuclearity homo and heterometallic aggregates, the ability of the mentioned ring to activate the C-Cl bond, and its spontaneous evolution in the presence of Brönsted acids (HCl, HClO4) will be studied. These results will be compared with the experimental and theoretical data already obtained for the diphosphine analog. In the field of bioinorganic chemistry, we aim at studying the specific functions of metallothioneins (MT), nowadays still a matter of debate. The synthesis of Callinectes sapidus MTIII-CALSI protein, which embodies Cys triplets, will be undertaken by means of genetic engineering techniques (...)
StatusFinished
Effective start/end date13/12/0412/12/07

Funding

  • Ministerio de Educación y Ciencia: €79,350.00

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