Alzheimer disease (AD) is characterized by the presence of two structural alterations of brain cortex, senile plaques and neurofibrillary tangles. The neuronal degeneration of AD brains appears to be accompanied by a massive regenerative response, for the search of inherent neurotrophic activities to AD is the subject of many studies. In an "in vitro" model developed with cortical rat neurons it has been found that brain extracts from AD brains possess a higher neurotrophic activity than those form control brains.Some studies demonstrate that difference is due to the decrease of an inhibitory factor of neuron survival in AD brains, and suggest that this decrease could contribute decissively to the excessive neuronal response and subsequent death typical of this disease. The inhibitory factor, initially called GIF (growth inhibitory factor), has been found to be a member of the metallothi
|Effective start/end date||26/04/96 → 26/04/99|
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