Genotoxicitat en eucariotes. Nous estudis sobre mecanismes i detecció

  • Marcos Dauder, Ricardo (Principal Investigator)
  • Baldrich Rubio, Eva (Scholar)
  • Cabré Fabré, Oriol (Investigator)
  • Carbonell Teruel, Elisabet (Investigator)
  • Creus Capdevila, Amadeu (Investigator)
  • Pitarque Marti, Maria (Investigator)
  • Soriano Valverde, Silvia (Investigator)
  • Suarez Figueras, Susana (Investigator)
  • Torres Turon, Carme (Investigator)
  • Velazquez Henar, Maria Antonia (Investigator)
  • Xamena Lopez, Noel (Investigator)

Project Details

Description

Following the research developed by our group on the study of several genotoxicity assays and on their ability to detect different kinds of genetic damage, the present project plans : 1) "Drosophila melanogaster" strains bearing transposable elements inserted in the "locus white", will be heat-shock treated to induce revertant phenotypes and to characterize them at molecular level in order to explain the nature of the induced mutagenic events; 2) to identify and characterize "Drosophila melanogaster" mismatch repair deficient mutants using the AP-PCR method; 3) biomonitoring of a population of patients with thyroid cancer of hyperthyroidism treated with "131-I", by analysing the different types of genetic damage induced in their peripheral blood lymphocytes, using both classic cytogenetic and "in situ" hybridization techniques; and 4) to evaluate the microgel electroforesis assay ("Comet
StatusFinished
Effective start/end date1/07/951/07/98

Funding

  • Comisión Interministerial de Ciencia y Tecnología (CICYT)

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