Funció del sistema enzimàtic de l'alcohol deshidrogenasa en l'estrès oxidatiu causat pel consum crònic d'etanol

  • Farres Vicen, Jaime (Principal Investigator)
  • Biosca Vaque, Josep Antoni (Investigator)
  • Gutierrez Fornes, Cristina (Investigator)
  • Marsal, Francesc Vidal (Investigator)
  • Pastor Garcia, Conxita (Investigator)
  • Peralba Polo, Josep Maria (Investigator)
  • Sabrià Pau, Josefa (Investigator)

Project Details

Description

The main objective of this study is to assess the protective role that alcohol dehydrogenase (ADH) may offer against oxidative stress during chronic ethanol consumption. Three groups of samples will be analyzed: samples obtained from fifty chronic alcoholic patients and from fifty healthy subjects, as a control; samples obtained from rats fed chronically with ethanol, and samples from hepatoma cell culture. Two parameters indicating oxidative stress will be determined: lipid peroxidation products (malondialdehyde and 4-hydroxynonenal) and antioxidant status (alfa-tocopherol and glutathione). The results obtained will be correlated with ADH genotypes in humans and determination of ADH activity levels in rat and cell culture samples.
StatusFinished
Effective start/end date1/01/9431/12/96

Funding

  • Fondo de Investigación Sanitaria: €55,894.13

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