The purpose of this study is to reach a better understanding of the structure and function of canine cutaneous mast cells (CMC), particularly of the role played by these cells in the pathogenesis of atopic dermatitis. The final aim of the project is to establish canine atopic dermatitis as a convenient model for the study of this disease in humans. Immunohistochemical and ultraestructural studies will be performed on cutaneous MC obtained from healthy and atopic dogs, mixed cultures of mast cells and fibroblasts will be established, the production and releases of inflammatory mediators will be measured (histamine, PAF, eicosanoids) and the possible regulatory effect of several compounds (antihistamines, anti-PAF, 5-lipoxygenase inhibitors and phosphodiesterase inhibitors) will also be examined.
|Effective start/end date||8/07/94 → 8/07/97|
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