Over the last years, the combination of cytogenetics and molecular biology has allowed the localization of genes that are important in the processes of tumor initiation and progression. Trisomy 7 is a frequent alteration in both renal and bladder tumors. Previous studies have shown that several genes located in this chromosome (EGFR, PDGF-A) are involved in cell proliferation and invasiveness. While some authors have detected a correlation between high levels of EGF Receptor and invasiveness capacity, little is known about PDGF-A. For that reason we want to analyze the expression of both genes, and correlate it with chromosome 7 alterations and tumoral phenotype. On the other hand, the cytogenetic results show a loss of specific chromosomonal regions during the progression of bladder tumors: 3p14-21, 6q21, 9q11-21, 11p15.5, 17p13. Some of these alterations are also common in renal cell c
|Effective start/end date
|22/06/92 → 22/06/95
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