Diabetes mellitus is the most common metabolic disease in humans. All forms of diabetes are characterized by hyperglycemia, an absolute or relative lack of insulin, and development of diabetes-specific microvascular pathology, neurological complications and atherosclerosis. In spite of an immense investment of resources, a clear understanding of the basic pathogenic mechanims of diabetes has not yet emerged. Conventional approaches do not provide further insights in the comprehension of this process. The generation of transgenic animal models of diabetes, in which a specific gene is altered, may be useful in the comprehension of the pathogenic mechanisms responsible for the diabetic complications. We have recently obtained transgenic mice overexpressing IGF-I in B-cells. Preliminary results indicate that these animals develop diabetes and the long-term complications of the disease (cataracts, glaucoma, retinopathy, etc.) In this project, we will study the effects of IGF-I and IGF-II in the pathogenesis of diabetes \i mellitus\i0 and the specific mechanisms responsible for the secondary complications, using transgenic mice.These animals will be useful in the design of new therapeutical approaches to prevent the serious long-term complications of diabetes \i mellitus\i0 .
|Effective start/end date||1/01/95 → 31/12/97|