The aim of this project is the study of the interaction between the mechanisms regulating the intestinal motility and the immune system of the gut. Most of the gastrointestinal disorders are due to inflammatory processes which induce changes on the motor activity of the intestine. Furthermore, the fact that the gastrointestinal tract is continuosly exposed to diversity of potential pathogen agents gives strength to the hypothesis that the interaction between the neuroendocrine and immune system is necessary to maintain physiological state in the intestine. Our project is based in three hypothesis: 1) There is a interaction between the mast cells of the mucosa and the mechanism regulating motor patterns; 2) during the inflammatory process, both functional and morphological changes take place in the structures regulating gastrointestinal motility (extrinsic pathways, enteric nervous system) as well as in the smooth muscle; and 3) Some of these changes might remain after the inflammatory process is over, leaving permanent alterations of both mobility and perception.
|Effective start/end date||6/07/96 → 6/07/99|