Malignant melanoma (MM) is the most aggressive form of skin cancer and its incidence is increasing fast all over the world. Death is due to the ability of melanoma cells to metastasise and early diagnosis is still the only way to prevent it. The main goal of the present project is to improve the molecular technologies to diagnose high-risk cases and to increase our knowledge of genetic and cellular factors which are involved in melanoma formation and progression. This project aims to the following aspects: -To improve diagnosis and prognosis for dysplastic nevi, primary melanoma and mestastatic melanoma by using comparative genomic hybridisation (CGH), gene expression microarray profiles and analysis of extracellular matrix-related molecules by immunohistochemistry. -Characterization of the process of melanoma tumor progression in melanoma cell lines originated from human melanomas and biopsies from nevi and primary and metastatic melanoma: chromosomal abnormalities, gene expression and expression of molecules related with adhesion and migration. -Study of the signal transduction pathways triggered by versican/hyaluronic acid/CD44 and by decorin and their functional roles in melanoma cells. -Evaluation of the validity of canine melanoma as a model for human melanoma.
|Effective start/end date||15/12/03 → 14/12/06|
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